Distinguished from all other species of Hemiancistrus except H. chlorostictus, H. votouro, H. megacephalus and H. macrops by the presence of light dots on all fins and the lateral and dorsal portions of body. H. meizospilos differs from H. chlorostictus and H. votouro by the much larger light markings (one large dot occupying one to three plates vs. one to three dots per plate) and from H. votouro by the larger orbit diameter (16.7-21.0% HL vs. 14.5-16.7% HL). H. meizospilos is distinguished from H. megacephalus and H. macrops by the area that light dots occupying each body plate (one large dot occupying one to three plates and skin between them vs. one large dot occupying only one body plate) (Ref. 54753).